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Certain drugs in this class may increase the likelihood of diabetes and hypertension, but cardiovascular risk factors can be managed.
Research on the links between tenofovir and other antiretrovirals, SARS-CoV-2 infection and COVID severity has produced mixed results.
Once-daily Biktarvy, long-acting injectable Cabenuva and two-drug combos containing dolutegravir can keep HIV in check for years.
Switching from TAF to TDF may help people lose weight, but this must be balanced against the risk of kidney problems and bone loss.
The updated guidance says antiretroviral therapy should be started as soon as possible after diagnosis and outlines the latest options.
The long-acting injectable regimen suppressed HIV in more than 90% of study participants, including those with obesity.
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